This post picks up from a few missives ago (Mitigating Heterocyclic Metabolism, Part One) when I was pointing out the fantastic St. Jean and Fotsch Perspective article “Mitigating heterocycle metabolism in drug discovery” [Journal of Medicinal Chemistry 2012, 55(13), 6002-6020].  If you didn’t get a chance to read it, please feel free to examine my […]

I was digging back through my pile of literature to be read this weekend and came across this Perspective article “Mitigating heterocycle metabolism in drug discovery” written by discovery scientists St. Jean and Fotsch at Amgen’s Department of Therapeutic Discovery in California [Journal of Medicinal Chemistry 2012, 55(13), 6002–6020].  Turns out this was a pretty […]