This week on Monday, March 10 was the start of 2014 Brain Awareness Week worldwide, a global campaign founded by the Dana Alliance for Brain Initiatives in 1996 that sets aside a week every year to raise awareness of the benefits and advancement of brain research across the planet. More than 600 events are taking […]

Since 2007, I’ve served as part of the writing team for my company’s monthly in-house BenchMarks newsletter (under the dubious title of Science Editor), and one of my ongoing duties is to produce short synopses of journal articles published by our company scientists during the year.  One of my favorite duties is the annual “Publications […]

This post picks up from a few missives ago (Mitigating Heterocyclic Metabolism, Part One) when I was pointing out the fantastic St. Jean and Fotsch Perspective article “Mitigating heterocycle metabolism in drug discovery” [Journal of Medicinal Chemistry 2012, 55(13), 6002-6020].  If you didn’t get a chance to read it, please feel free to examine my […]

This is another entry in my ongoing mission to provide short synopses of journal articles published by AMRI scientists.  In this case I summarize a recent manuscript describing an independent research effort, developed by my Medicinal Chemistry colleague Robert Kargbo.  Within AMRI, as in many pharma discovery organizations, we are encouraged to find ways to […]

I recently attended a scientific conference where a friend of mine described some historical research for a BMS program to develop novel small molecule antagonists of the calcitonin gene-related peptide (CGRP) receptor for the treatment of migraine.  (Disclaimer: I will not be disclosing anything confidential presented at this meeting—the data and discussion that follows here is drawn from […]